124 research outputs found
Beaming Binaries - a New Observational Category of Photometric Binary Stars
The new photometric space-borne survey missions CoRoT and Kepler will be able
to detect minute flux variations in binary stars due to relativistic beaming
caused by the line-of-sight motion of their components. In all but very short
period binaries (P>10d), these variations will dominate over the ellipsoidal
and reflection periodic variability. Thus, CoRoT and Kepler will discover a new
observational class: photometric beaming binary stars. We examine this new
category and the information that the photometric variations can provide. The
variations that result from the observatory heliocentric velocity can be used
to extract some spectral information even for single stars.Comment: 15 pages, 4 figures, accpeted for publication in The Astrophysical
Journa
Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes
Many types of tumors exhibit chromosomal losses or gains, as well as local
amplifications and deletions. Within any given tumor type, sample specific
amplifications and deletionsare also observed. Typically, a region that is
aberrant in more tumors,or whose copy number change is stronger, would be
considered as a more promising candidate to be biologically relevant to cancer.
We sought for an intuitive method to define such aberrations and prioritize
them. We define V, the volume associated with an aberration, as the product of
three factors: a. fraction of patients with the aberration, b. the aberrations
length and c. its amplitude. Our algorithm compares the values of V derived
from real data to a null distribution obtained by permutations, and yields the
statistical significance, p value, of the measured value of V. We detected
genetic locations that were significantly aberrant and combined them with
chromosomal arm status to create a succint fingerprint of the tumor genome.
This genomic fingerprint is used to visualize the tumors, highlighting events
that are co ocurring or mutually exclusive. We allpy the method on three
different public array CGH datasets of Medulloblastoma and Neuroblastoma, and
demonstrate its ability to detect chromosomal regions that were known to be
altered in the tested cancer types, as well as to suggest new genomic locations
to be tested. We identified a potential new subtype of Medulloblastoma, which
is analogous to Neuroblastoma type 1.Comment: 34 pages, 3 figures; to appear in Cancer Informatic
Spectroscopic Binary Mass Determination using Relativity
High-precision radial-velocity techniques, which enabled the detection of
extrasolar planets are now sensitive to relativistic effects in the data of
spectroscopic binary stars (SBs). We show how these effects can be used to
derive the absolute masses of the components of eclipsing single-lined SBs and
double-lined SBs from Doppler measurements alone. High-precision stellar
spectroscopy can thus substantially increase the number of measured stellar
masses, thereby improving the mass-radius and mass-luminosity calibrations.Comment: 10 pages, 1 figure, accepted for publication by the Astrophysical
Journal Letter
Is Image Memorability Prediction Solved?
This paper deals with the prediction of the memorability of a given image. We
start by proposing an algorithm that reaches human-level performance on the
LaMem dataset - the only large scale benchmark for memorability prediction. The
suggested algorithm is based on three observations we make regarding
convolutional neural networks (CNNs) that affect memorability prediction.
Having reached human-level performance we were humbled, and asked ourselves
whether indeed we have resolved memorability prediction - and answered this
question in the negative. We studied a few factors and made some
recommendations that should be taken into account when designing the next
benchmark
Structural Insight into Regulation of the Proteasome Ub-Receptor Rpn10
Ubiquitylation is a posttranslational modification that determines protein fate. The ubiquitin code is written by enzymatic cascades of E1 and E2 and E3 enzymes. Ubiquitylation can be edited or erased by deubiquitylating enzymes. Ub-receptors are proteins that read and decipher the ubiquitin codes into cellular response. They harbor a ubiquitin-binding domain and a response element. Interestingly, Ub-receptors are also regulated by ubiquitylation and deubiquitylation. However, until recently, the molecular details and the significance of this regulation remained enigmatic. Rpn10 is a Ub-receptor that shuttles ubiquitylated targets to the proteasome for degradation. Here we review recent data on Rpn10, with emphasis on its regulation by ubiquitylation
Probing Post-Newtonian Gravity near the Galactic Black Hole with Stellar Doppler Measurements
Stars closely approaching the massive black hole in the center of the Galaxy
provide a unique opportunity to probe post-Newtonian physics in a yet
unexplored regime of celestial mechanics. Recent advances in infrared stellar
spectroscopy allow the precise measurement of stellar Doppler shift curves and
thereby the detection of beta-squared post-Newtonian effects (gravitational
redshift in the black hole's potential and the transverse Doppler shift). We
formulate a detection procedure in terms of a simplified post-Newtonian
parametrization. We then use simulations to show that these effects can be
decisively detected with existing instruments after about a decade of
observations. We find that neglecting these effects can lead to statistically
significant systematic errors in the derived black hole mass and distance.Comment: 4 pages, 3 figures, submitted to The Astrophysical Journal Letter
Occurrence rates of small planets from HARPS: Focus on the Galactic context
Context. The stars in the Milky Way thin and thick disks can be distinguished
by several properties such as metallicity and kinematics. It is not clear
whether the two populations also differ in the properties of planets orbiting
the stars. In order to study this, a careful analysis of both the chemical
composition and mass detection limits is required for a sufficiently large
sample. Currently, this information is still limited only to large
radial-velocity (RV) programs. Based on the recently published archival
database of the High Accuracy Radial velocity Planet Searcher (HARPS)
spectrograph, we present a first analysis of low-mass (small) planet occurrence
rates in a sample of thin- and thick-disk stars. Aims. We aim to assess the
effects of stellar properties on planet occurrence rates and to obtain first
estimates of planet occurrence rates in the thin and thick disks of the Galaxy.
As a baseline for comparison, we also aim to provide an updated value for the
small close-in planet occurrence rate and compare it to results of previous RV
and transit () works. Methods. We used archival HARPS RV
datasets to calculate detection limits of a sample of stars that were
previously analysed for their elemental abundances. For stars with known
planets we first subtracted the Keplerian orbit. We then used this information
to calculate planet occurrence rates according to a simplified Bayesian model
in different regimes of stellar and planet properties. Results. Our results
suggest that metal-poor stars and more massive stars host fewer low-mass
close-in planets. We find the occurrence rates of these planets in the thin and
thick disks to be comparable. In the iron-poor regimes, we find these
occurrence rates to be significantly larger at the high- region
(thick-disk stars) as compared with the low- region (thin-disk stars).
In general, we find the...Comment: 10 pages, 6 figures, accepted for publication in A&
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